Torsades De Pointes Following Concurrent Amiodarone and Levofloxacin Therapy

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Torsades de pointes following concurrent amiodarone and levofloxacin therapy.

A case of torsades de pointes is reported following administration of amiodarone concurrent with the fluoroquinolone levofloxacin. Prolongation of the QTc interval has occurred with the fluoroquinolone class of antibiotics. The incidence of torsades has been considered rare with amiodarone. Caution is warranted when these two agents are administered concurrently.

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Torsades de pointes is a polymorphic ventricular tachycardia that can quickly evolve into ventricular fibrillation and sudden death. This arrhythmia often occurs secondary to medication- induced cardiac repolarization dysfunction with resultant prolonged QTc interval on ECG. Numerous medications can predispose patients to this deadly tachycardia. We report a case of methadone-induced Torsades d...

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Torsades de pointes: unanswered questions.

Torsade de pointes (Tdp) is a polymorphic ventricular tachycardia (VT) in which the axis of the QRS complex changes direction after a certain number of complexes as if the complex rotated around the baseline. Tdp is usually associated with QT prolongation, and dispersion of ventricular repolarlization (DR). Experimental models of tdp are usually associated with induction of early after depolari...

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ژورنال

عنوان ژورنال: Baylor University Medical Center Proceedings

سال: 2006

ISSN: 0899-8280,1525-3252

DOI: 10.1080/08998280.2006.11928199